{"id":251,"date":"2026-06-10T21:34:45","date_gmt":"2026-06-10T13:34:45","guid":{"rendered":"https:\/\/word.hellsmart.top\/?p=251"},"modified":"2026-06-10T21:34:45","modified_gmt":"2026-06-10T13:34:45","slug":"%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%87%e6%99%9a%e6%8a%a5%ef%bc%9a%e8%a1%80%e6%b6%b2%e6%a0%87%e5%bf%97%e7%89%a9%e7%a0%94%e7%a9%b6%ef%bc%8c%e8%ae%a9%e9%95%bf%e6%9c%9f%e8%bf%bd%e8%b8%aa","status":"publish","type":"post","link":"https:\/\/word.hellsmart.top\/index.php\/2026\/06\/10\/%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%87%e6%99%9a%e6%8a%a5%ef%bc%9a%e8%a1%80%e6%b6%b2%e6%a0%87%e5%bf%97%e7%89%a9%e7%a0%94%e7%a9%b6%ef%bc%8c%e8%ae%a9%e9%95%bf%e6%9c%9f%e8%bf%bd%e8%b8%aa\/","title":{"rendered":"\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u665a\u62a5\uff1a\u8840\u6db2\u6807\u5fd7\u7269\u7814\u7a76\uff0c\u8ba9\u957f\u671f\u8ffd\u8e2a\u66f4\u63a5\u8fd1\u73b0\u5b9e"},"content":{"rendered":"<p>\u4eca\u5929\u533b\u5b66\u9886\u57df\u5173\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u4e00\u9879\u65b0\u7814\u7a76\uff0c\u6765\u81ea\u300aAlzheimer\u2019s Research &amp; Therapy\u300b\u3002\u7814\u7a76\u56e2\u961f\u57fa\u4e8e\u6cd5\u56fd MEMENTO \u961f\u5217\u7684 2299 \u540d\u53c2\u4e0e\u8005\uff0c\u5173\u6ce8\u4e24\u7c7b\u8840\u6db2\u751f\u7269\u6807\u5fd7\u7269\uff1ap-tau181 \u548c\u795e\u7ecf\u4e1d\u8f7b\u94fe NfL\u3002\u5b83\u4eec\u5e38\u88ab\u7528\u4e8e\u89c2\u5bdf\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u76f8\u5173\u75c5\u7406\u53d8\u5316\u548c\u795e\u7ecf\u635f\u4f24\u8d8b\u52bf\u3002<\/p>\n<p>\u8fd9\u9879\u7814\u7a76\u6700\u6709\u73b0\u5b9e\u610f\u4e49\u7684\u5730\u65b9\uff0c\u4e0d\u662f\u5ba3\u5e03\u67d0\u79cd\u65b0\u836f\u9a6c\u4e0a\u80fd\u6cbb\u6108\u75be\u75c5\uff0c\u800c\u662f\u89e3\u51b3\u957f\u671f\u7814\u7a76\u4e2d\u7684\u4e00\u4e2a\u201c\u57fa\u7840\u96be\u9898\u201d\uff1a\u68c0\u6d4b\u5de5\u5177\u4f1a\u66f4\u65b0\uff0c\u8bd5\u5242\u76d2\u4f1a\u53d8\u5316\uff0c\u4e0d\u540c\u5e74\u4efd\u6d4b\u5230\u7684\u6570\u636e\u5982\u4f55\u653e\u5728\u540c\u4e00\u6761\u65f6\u95f4\u7ebf\u4e0a\u6bd4\u8f83\uff1f\u7814\u7a76\u6bd4\u8f83\u4e86\u4f20\u7edf\u201c\u6865\u63a5\u7814\u7a76\u201d\u548c\u6f5c\u5728\u8fc7\u7a0b\u6a21\u578b\u4e24\u79cd\u65b9\u6cd5\uff0c\u53d1\u73b0\u540e\u8005\u867d\u7136\u5728\u6781\u7aef\u6570\u503c\u4e0a\u4ecd\u6709\u5dee\u5f02\uff0c\u4f46\u603b\u4f53\u80fd\u8f83\u597d\u6821\u6b63\u68c0\u6d4b\u53d8\u5316\uff0c\u51cf\u5c11\u989d\u5916\u6837\u672c\u91cd\u590d\u68c0\u6d4b\u7684\u6210\u672c\u3002<\/p>\n<p>\u8fd9\u542c\u8d77\u6765\u4e0d\u591f\u8f70\u52a8\uff0c\u5374\u5f88\u91cd\u8981\u3002\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u6cbb\u7597\u7684\u7a81\u7834\uff0c\u5f80\u5f80\u4e0d\u662f\u4e00\u5929\u7a81\u7136\u53d1\u751f\u7684\u3002\u5b83\u4f9d\u8d56\u66f4\u65e9\u53d1\u73b0\u3001\u66f4\u51c6\u5206\u578b\u3001\u66f4\u957f\u671f\u8ffd\u8e2a\uff0c\u4e5f\u4f9d\u8d56\u7814\u7a76\u8005\u628a\u51e0\u5e74\u751a\u81f3\u5341\u51e0\u5e74\u7684\u6570\u636e\u5c3d\u91cf\u63a5\u8d77\u6765\u3002\u8840\u6db2\u6807\u5fd7\u7269\u5982\u679c\u80fd\u66f4\u7a33\u5b9a\u5730\u670d\u52a1\u4e34\u5e8a\u548c\u7814\u7a76\uff0c\u5c31\u6709\u673a\u4f1a\u8ba9\u7b5b\u67e5\u66f4\u65b9\u4fbf\uff0c\u4e5f\u8ba9\u836f\u7269\u8bd5\u9a8c\u66f4\u9ad8\u6548\u3002<\/p>\n<p>\u6211\u5bf9\u8fd9\u4e2a\u75c5\u6709\u5f88\u6df1\u7684\u79c1\u4eba\u611f\u53d7\u3002\u6211\u7684\u5988\u5988\u5728 2017 \u5e74\u88ab\u786e\u8bca\uff0c\u5982\u4eca\u5979\u5df2\u7ecf\u5b8c\u5168\u4e0d\u8ba4\u8bc6\u6211\u4e86\uff0c\u53ef\u6709\u65f6\u4ecd\u4f1a\u63d0\u5230\u6211\u7684\u540d\u5b57\u3002\u90a3\u4e00\u523b\u5f88\u5fc3\u75db\uff0c\u56e0\u4e3a\u4f60\u77e5\u9053\u4eb2\u60c5\u8fd8\u50cf\u5fae\u5f31\u7684\u706f\u4e00\u6837\u5728\u90a3\u91cc\uff0c\u53ea\u662f\u8bb0\u5fc6\u7684\u8def\u88ab\u75be\u75c5\u4e00\u70b9\u70b9\u5c01\u4f4f\u4e86\u3002<\/p>\n<p>\u6240\u4ee5\u6211\u5e0c\u671b\u8fd9\u4e9b\u770b\u4f3c\u201c\u65b9\u6cd5\u5b66\u201d\u7684\u8fdb\u6b65\u4e0d\u8981\u88ab\u5ffd\u89c6\u3002\u771f\u6b63\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u4e5f\u8bb8\u6b63\u662f\u7531\u8fd9\u4e9b\u4e0d\u8000\u773c\u7684\u79ef\u7d2f\u94fa\u51fa\u6765\u7684\u3002\u613f\u533b\u5b66\u65e9\u4e00\u70b9\u518d\u65e9\u4e00\u70b9\uff0c\u628a\u66f4\u591a\u5bb6\u5ead\u4ece\u8fd9\u79cd\u6f2b\u957f\u7684\u544a\u522b\u4e2d\u62c9\u56de\u6765\u3002<\/p>\n<hr>\n<p><strong>\u53c2\u8003\u7814\u7a76\uff1a<\/strong> Bouteloup V \u7b49\uff0cMethodological approaches to account for assay changes in longitudinal biomarker analysis: insights from Alzheimer&#8217;s blood biomarkers in the MEMENTO cohort. Alzheimer&#8217;s Research &#038; Therapy\uff0c2026-06-10\uff0cDOI: 10.1186\/s13195-026-02042-3\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u65e5\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7814\u7a76\u5173\u6ce8\u8840\u6db2\u6807\u5fd7\u7269\u957f\u671f\u8ffd\u8e2a\u4e2d\u7684\u68c0\u6d4b\u6821\u6b63\u95ee\u9898\uff0c\u8fd9\u7c7b\u57fa\u7840\u8fdb\u6b65\u53ef\u80fd\u5e2e\u52a9\u66f4\u65e9\u53d1\u73b0\u3001\u66f4\u51c6\u8bc4\u4f30\uff0c\u4e5f\u4e3a\u6cbb\u7597\u7a81\u7834\u94fa\u8def\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[12],"tags":[9,41,42,4],"class_list":["post-251","post","type-post","status-publish","format-standard","hentry","category-12","tag-9","tag-41","tag-42","tag-4"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/posts\/251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/comments?post=251"}],"version-history":[{"count":1,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/posts\/251\/revisions"}],"predecessor-version":[{"id":252,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/posts\/251\/revisions\/252"}],"wp:attachment":[{"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/media?parent=251"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/categories?post=251"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/tags?post=251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}