{"id":329,"date":"2026-06-27T21:31:01","date_gmt":"2026-06-27T13:31:01","guid":{"rendered":"https:\/\/word.hellsmart.top\/?p=329"},"modified":"2026-06-27T21:31:01","modified_gmt":"2026-06-27T13:31:01","slug":"%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%87%e6%99%9a%e6%8a%a5-2026%e5%b9%b46%e6%9c%8827%e6%97%a5%ef%bc%9a%e6%9c%80%e6%96%b0%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e4%b8%8e%e4%b8%80%e4%bd%8d","status":"publish","type":"post","link":"https:\/\/word.hellsmart.top\/index.php\/2026\/06\/27\/%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%87%e6%99%9a%e6%8a%a5-2026%e5%b9%b46%e6%9c%8827%e6%97%a5%ef%bc%9a%e6%9c%80%e6%96%b0%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e4%b8%8e%e4%b8%80%e4%bd%8d\/","title":{"rendered":"\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u665a\u62a5 | 2026\u5e746\u670827\u65e5\uff1a\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u4e0e\u4e00\u4f4d\u5bb6\u5c5e\u7684\u5fc3\u58f0"},"content":{"rendered":"

\u5927\u5bb6\u597d\uff0c\u6b22\u8fce\u6536\u770b\u4eca\u5929\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u665a\u62a5\u30022026\u5e746\u670827\u65e5\uff0c\u5168\u7403\u79d1\u5b66\u5bb6\u4eec\u5728\u6297\u51fb\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u9053\u8def\u4e0a\u53c8\u8fc8\u51fa\u4e86\u575a\u5b9e\u7684\u6b65\u4f10\u3002\u4ee5\u4e0b\u662f\u672c\u5468\u503c\u5f97\u5173\u6ce8\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c\u3002<\/p>\n

\u4e00\u3001OLE\u5206\u5b50\uff1a\u8ba9\u5927\u8111\u514d\u75ab\u7ec6\u80de”\u91cd\u83b7\u65b0\u751f”<\/h3>\n

\u672c\u5468\u6700\u4ee4\u4eba\u632f\u594b\u7684\u6d88\u606f\u6765\u81ea\u897f\u73ed\u7259\u548c\u745e\u58eb\u7684\u8054\u5408\u7814\u7a76\u56e2\u961f\u3002\u4ed6\u4eec\u53d1\u73b0\u4e00\u79cd\u540d\u4e3aOLE\u7684\u5b9e\u9a8c\u6027\u5206\u5b50\uff0c\u80fd\u591f”\u91cd\u65b0\u7f16\u7a0b”\u5927\u8111\u4e2d\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\u2014\u2014\u8fd9\u4e9b\u672c\u5e94\u4fdd\u62a4\u5927\u8111\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u60a3\u8005\u4f53\u5185\u9010\u6e10\u5931\u53bb\u529f\u80fd\u3002\u7814\u7a76\u663e\u793a\uff0cOLE\u5206\u5b50\u80fd\u5e2e\u52a9\u5c0f\u80f6\u8d28\u7ec6\u80de\u91cd\u65b0\u805a\u96c6\u5230\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u5468\u56f4\uff0c\u5f62\u6210\u5c4f\u969c\u9650\u5236\u6591\u5757\u5bf9\u795e\u7ecf\u5143\u7684\u6bd2\u6027\u5f71\u54cd\u3002\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c\u7ecf\u8fc7\u6cbb\u7597\u7684\u5c0f\u9f20\u5728\u8bb0\u5fc6\u6d4b\u8bd5\u4e2d\u8868\u73b0\u51fa\u4e86\u660e\u663e\u6539\u5584\u3002\u8fd9\u9879\u6210\u679c\u53d1\u8868\u5728\u300aCell Death and Disease\u300b\u671f\u520a\u4e0a\u3002<\/p>\n

\u4e8c\u3001”Compound 10″\uff1a\u4e8c\u5341\u5e74\u78e8\u4e00\u5251\u7684\u65b0\u9776\u70b9\u7a81\u7834<\/h3>\n

\u82cf\u9ece\u4e16\u8054\u90a6\u7406\u5de5\u5b66\u9662\uff08ETH Zurich\uff09\u56e2\u961f\u7ecf\u8fc7\u8fd1\u4e8c\u5341\u5e74\u7684\u7814\u7a76\uff0c\u53d1\u73b0\u4e86\u4e00\u79cd\u540d\u4e3aGRK2\u7684\u86cb\u767d\u8d28\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u4e2d\u626e\u6f14\u7740\u5173\u952e\u89d2\u8272\u3002GRK2\u7684\u5931\u6d3b\u5f62\u5f0f\u4f1a\u5728\u795e\u7ecf\u5143\u5185\u805a\u96c6\uff0c\u9644\u7740\u5728\u7ebf\u7c92\u4f53\u4e0a\u5e72\u6270\u5176\u529f\u80fd\u3002\u4ed6\u4eec\u5f00\u53d1\u7684\u5b9e\u9a8c\u6027\u5316\u5408\u7269”Compound 10″\u80fd\u591f\u963b\u65ad\u8fd9\u4e00\u7834\u574f\u8fc7\u7a0b\uff0c\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u51cf\u5c11\u4e86\u795e\u7ecf\u7ec6\u80de\u635f\u5931\uff0c\u5ef6\u957f\u4e86\u5c0f\u9f20\u5bff\u547d\u3002\u8fd9\u4e00\u6210\u679c\u53d1\u8868\u5728\u300aCell Reports Medicine\u300b\u4e0a\uff0c\u6709\u671b\u5f00\u8f9f\u5168\u65b0\u7684\u6cbb\u7597\u8def\u5f84\u3002<\/p>\n

\u4e09\u30012026\u5e74\u6cbb\u7597\u683c\u5c40\uff1a\u4ece\u5355\u9776\u70b9\u5230\u591a\u7ba1\u9f50\u4e0b<\/h3>\n

2026\u5e74\u4e0a\u534a\u5e74\uff0cFDA\u5df2\u6279\u51c6\u591a\u79cd\u75be\u75c5\u4fee\u9970\u7597\u6cd5\u3002\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u5355\u514b\u9686\u6297\u4f53\uff08\u5982\u4ed1\u5361\u5948\u5355\u6297\u3001\u591a\u5948\u5355\u6297\uff09\u5728\u65e9\u671f\u60a3\u8005\u4e2d\u663e\u793a\u51fa27-35%\u7684\u8ba4\u77e5\u8870\u9000\u51cf\u7f13\u6548\u679c\u3002\u9776\u5411tau\u86cb\u767d\u7684\u65b0\u836f\u8fdb\u5165\u4e09\u671f\u4e34\u5e8a\uff0cGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u4e5f\u88ab\u8bc1\u5b9e\uff0c\u8054\u5408\u7597\u6cd5\u6b63\u6210\u4e3a\u65b0\u8d8b\u52bf\u3002\u6bd4\u5c14\u00b7\u76d6\u8328\u8fd1\u65e5\u4e5f\u516c\u5f00\u8868\u793a\uff1a\u5bf9\u6297\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6b63\u8fce\u6765\u8f6c\u6298\u70b9\uff0c\u65b0\u7597\u6cd5\u843d\u5730\u901f\u5ea6\u6b63\u5728\u52a0\u5feb\u3002<\/p>\n

\u56db\u3001\u4e00\u4f4d\u5bb6\u5c5e\u7684\u5fc3\u58f0<\/h3>\n

\u770b\u5230\u8fd9\u4e9b\u8fdb\u5c55\uff0c\u6211\u7684\u5fc3\u60c5\u5f88\u590d\u6742\u3002\u6211\u5988\u59882017\u5e74\u88ab\u786e\u8bca\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\uff0c\u5230\u73b0\u5728\u5df2\u7ecf\u5feb\u5341\u5e74\u4e86\u3002\u5979\u5df2\u7ecf\u5b8c\u5168\u4e0d\u8ba4\u8bc6\u6211\u4e86\uff0c\u4f46\u6709\u65f6\u5019\u8fd8\u4f1a\u7a81\u7136\u63d0\u5230\u6211\u7684\u540d\u5b57\u2014\u2014\u6bcf\u5f53\u542c\u5230\u5979\u5634\u91cc\u8bf4\u51fa\u6211\u7684\u540d\u5b57\uff0c\u6211\u7684\u5fc3\u5c31\u50cf\u88ab\u5200\u5272\u4e00\u6837\u3002\u5979\u8bb0\u5f97\u8fd9\u4e2a\u540d\u5b57\uff0c\u5374\u4e0d\u8bb0\u5f97\u8fd9\u4e2a\u540d\u5b57\u5bf9\u5e94\u7684\u4eba\u662f\u8c01\u3002<\/p>\n

\u8fd9\u4e9b\u5e74\u770b\u7740\u5979\u4e00\u6b65\u6b65\u9057\u5fd8\u4e16\u754c\u3001\u88ab\u4e16\u754c\u9057\u5fd8\uff0c\u90a3\u79cd\u65e0\u529b\u611f\u65e0\u6cd5\u7528\u8bed\u8a00\u5f62\u5bb9\u3002\u6211\u5e38\u5e38\u5728\u60f3\uff0c\u5982\u679c\u80fd\u65e9\u4e00\u4e9b\u3001\u54ea\u6015\u65e9\u4e00\u5e74\u6709\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u7ed3\u5c40\u4f1a\u4e0d\u4f1a\u4e0d\u540c\uff1f<\/p>\n

\u6b63\u662f\u56e0\u4e3a\u6709\u592a\u591a\u50cf\u6211\u5988\u5988\u4e00\u6837\u88ab\u8fd9\u4e2a\u75be\u75c5\u593a\u8d70\u8bb0\u5fc6\u7684\u60a3\u8005\uff0c\u6709\u592a\u591a\u50cf\u6211\u4e00\u6837\u5728\u714e\u71ac\u4e2d\u7b49\u5f85\u7684\u5bb6\u5ead\uff0c\u79d1\u5b66\u5bb6\u4eec\u7684\u6bcf\u4e00\u4e2a\u7a81\u7834\u624d\u5982\u6b64\u73cd\u8d35\u3002OLE\u5206\u5b50\u3001Compound 10\u3001\u65b0\u7684\u8054\u5408\u7597\u6cd5\u2026\u2026\u867d\u7136\u5b83\u4eec\u5927\u591a\u8fd8\u5728\u5b9e\u9a8c\u9636\u6bb5\uff0c\u4f46\u6bcf\u4e00\u6761\u597d\u6d88\u606f\u90fd\u50cf\u4e00\u675f\u5149\u3002\u5e0c\u671b\u6709\u4e00\u5929\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u4e0d\u518d\u610f\u5473\u7740”\u65e0\u6cd5\u9006\u8f6c\u7684\u544a\u522b”\u3002<\/p>\n

\u613f\u79d1\u7814\u52a0\u901f\uff0c\u613f\u8bb0\u5fc6\u957f\u5b58\u3002<\/p>\n

\u2014\u2014 \u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u665a\u62a5 \u00b7 \u6bcf\u5929\u5173\u6ce8\u524d\u6cbf\u8fdb\u5c55 \u00b7 2026\u5e746\u670827\u65e5<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5927\u5bb6\u597d\uff0c\u6b22\u8fce\u6536\u770b\u4eca\u5929\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u665a\u62a5\u30022026\u5e746\u670827\u65e5\uff0c\u5168\u7403\u79d1\u5b66\u5bb6\u4eec\u5728\u6297\u51fb\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u9053\u8def\u4e0a\u53c8\u8fc8\u51fa\u4e86\u575a […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-329","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/posts\/329","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/comments?post=329"}],"version-history":[{"count":1,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/posts\/329\/revisions"}],"predecessor-version":[{"id":330,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/posts\/329\/revisions\/330"}],"wp:attachment":[{"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/media?parent=329"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/categories?post=329"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/word.hellsmart.top\/index.php\/wp-json\/wp\/v2\/tags?post=329"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}